...To begin with, the believer's body is God's temple, and He wants to use it for His glory. But Paul wrote that the body is also God's tool and weapon.
Romans 6:13 Neither yield ye your members as instruments of unrighteousness unto sin but yield yourselves unto God, as those that are alive from the dead, and your members as instruments of righteousness unto God.
God wants to use the members of the body as tools for building His kingdom and weapons for fighting His enemies.
God used the rod in Moses' hand and conquered Egypt. He used the sling in David's hand to defeat the Philistines. He used the mouths and tongues of the prophets. Paul's dedicated feet carried him from city to city as he proclaimed the Gospel. The Apostle John's eyes saw visions of the future, his ears heard God's message, and his fingers wrote it all down in a book that we can read.
Why should we yield to God? A three word summary: Favor -- Freedom -- Fruit.