The Apostle Paul’s thorn was “in the flesh”. The thorns and buffetings we endure in this life are often physical, some are emotional--- depression, loneliness and heartbreak, and some are spiritual--- doubting our salvation, struggling with holiness or pride. Paul lived with his thorn all the time. Three times he asked God for relief.
2 Corinthians 12:9-10 And he said unto me, My grace is sufficient for thee: for my strength is made perfect in weakness. Most gladly therefore will I rather glory in my infirmities, that the power of Christ may rest upon me. Therefore I take pleasure in infirmities, in reproaches, in necessities, in persecutions, in distresses for Christ's sake: for when I am weak, then am I strong.
When the path of life is easy we often forget how much we need the Lord. It may take a "thorn in the flesh" to shock us back to reality, to seek God..
“My strength is made perfect in weakness”, means that God gets more glory from using the weak things of the world. Paul took pleasure in infirmities, reproaches, necessities, persecutions and distresses for Christ’s sake. For when he was weak, then was he made strong in the Lord.